Title :
A biosensor for detection of DNA sequences based on a 50MHz QCM electronic oscillator circuit
Author :
Bustabad, E.A. ; García, G. ; Rodriguez-Pardo, L. ; Faria, J. ; Perrot, H. ; Gabrielli, C. ; Bucur, B. ; Lazerges, M. ; Rose, D. ; Compère, C. ; Arnau, A.
Author_Institution :
Dipt. Tecnol. Electron., Univ. de Vigo, Vigo, Spain
Abstract :
This work deals with the development of a high sensibility DNA biosensor based on a 50MHz Quartz Crystal Microbalance (QCM) Oscillator Electronic Circuit. The designed QCM oscillator sensor is able to detect the presence of complementary DNAs in a solution that match the sequence on a given strand in function of the changes in the output frequency of the oscillator. The design is adapted so that the Barkhausen condition is satisfied even when the quartz is immerged in liquid media. Also a comparative study of the developed 50MHz biosensor in front of a QCM oscillator with smaller frequency is carried out, with object of checking if the sensibility of the oscillator increases, allowing to detect smaller concentrations of the complementary DNA.
Keywords :
DNA; biosensors; circuit oscillations; crystal oscillators; microbalances; molecular biophysics; Barkhausen condition; DNA sequence detection; QCM electronic oscillator circuit; QCM oscillator sensor; biosensor; complementary DNA; frequency 50 MHz; oscillator output frequency; quartz crystal microbalance; Biosensors; Circuits; Crystalline materials; DNA; Electrodes; Frequency; Object detection; Oscillators; Q factor; Sequences;
Conference_Titel :
Sensors, 2009 IEEE
Conference_Location :
Christchurch
Print_ISBN :
978-1-4244-4548-6
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2009.5398346
