Title :
Class-based CMOS capacitive sensors for dopamine detection
Author :
Chen, Lei-Guang ; Lu, Michael S C
Author_Institution :
Dept. of Electr. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
The glass-based LTPS (low temperature polysilicon) TFT (thin-film transistor) process, as widely known for making liquid crystal displays, is utilized for the first time to make CMOS capacitive sensors for dopamine detection. Dopamine plays important roles in human behavior, cognition, and motor activity. The interface capacitance change, after its binding with 4-carboxyphenylboronic acid (CPBA), was detected by interdigitated microelectrodes and integrated sensing circuits. Three sensor designs showed measured sensitivities of -3.9 fF/mM, -5.4 fF/mM, and -7.2 fF/mM, respectively. The minimum detectable capacitance changes were 12.7 aF, 14.7 aF, and 13.5 aF, equivalent to detectable dopamine concentrations of 3.2 μM, 2.7 μM, and 1.9 μM, respectively.
Keywords :
CMOS integrated circuits; biosensors; capacitive sensors; chemical sensors; lab-on-a-chip; microelectrodes; molecular biophysics; organic compounds; 4-CPBA; 4-carboxyphenylboronic acid; class-based CMOS capacitive sensor; detectable dopamine concentration; dopamine detection; glass-based LTPS TFT process; glass-based low temperature polysilicon thin-film transistor process; integrated sensing circuit; interdigitated microelectrode; interface capacitance change; liquid crystal display; minimum detectable capacitance change; Biosensors; Capacitance; Capacitive sensors; Frequency measurement; Microelectrodes;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2011 IEEE International Conference on
Conference_Location :
Kaohsiung
Print_ISBN :
978-1-61284-775-7
DOI :
10.1109/NEMS.2011.6017480
