DocumentCode
3290551
Title
Evolutionary game theoretical approach for understanding CCR5 to CXCR4 coreceptor switch
Author
Jing Wu ; Bewick, S. ; Ruoting Yang ; Lenaghan, S.C. ; Mingjun Zhang
Author_Institution
Dept. of Mech., Aerosp. & Biomed. Eng., Univ. of Tennessee, Knoxville, TN, USA
fYear
2010
fDate
June 30 2010-July 2 2010
Firstpage
6722
Lastpage
6727
Abstract
This paper shows how a game theoretical analysis can provide a model to determine the factors affecting the switch from CXCR4 coreceptor (X4) to CCR5 coreceptor (R5) in HIV-1 infected individuals. Simulations of the model predict that a persistent immune response suppresses the X4-tropic virus to a low level at first, but later increases in the immune response will trigger the switch from X4 to R5 coreceptor. In addition, we find various factors that impact the switching time.
Keywords
cellular biophysics; game theory; microorganisms; molecular biophysics; proteins; CCR5 coreceptor; CXCR4 coreceptor; HIV-1; X4-tropic virus; game theoretical analysis; immune response; switching time; Acquired immune deficiency syndrome; Biological system modeling; Capacitive sensors; Evolution (biology); Game theory; Genetic mutations; Human immunodeficiency virus; Immune system; Switches; Viruses (medical);
fLanguage
English
Publisher
ieee
Conference_Titel
American Control Conference (ACC), 2010
Conference_Location
Baltimore, MD
ISSN
0743-1619
Print_ISBN
978-1-4244-7426-4
Type
conf
DOI
10.1109/ACC.2010.5531370
Filename
5531370
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