Title :
Monte Carlo simulation of the microPET FOCUS system for small rodents imaging applications
Author :
Jan, S. ; Desbree, A. ; Pain, F. ; Guez, D. ; Comtat, C. ; Gurden, H. ; Kerhoas, S. ; Lanièce, P. ; Lefebvre, F. ; Mastrippolito, R. ; Trebossen, R.
Author_Institution :
Service Hospitalier Frederic Joliot, CEA, Orsay
Abstract :
In this paper, the authors validated the microPET FOCUS modelling with GATE. The performances of this Monte Carlo platform were presented on voxelized rat brain phantom, specially for the simulation of realistic [C-11]Raclopride exam with a realistic modelling of the injected dose and acquisition time. These results are the consequence of complete installation of this Monte Carlo platform simulation on a cluster computing architecture. Finally, the authors showed a first preliminary approach to improve the quantitative analysis in rat brain dopaminergic studies with an implementation of corrections about the positron range and gamma accolinearity effects. In the future, these corrections could be included as priors in a maximum a posteriori reconstruction algorithm. Moreover, the simulation of whole body exams can be planned in order to optimize the quantitative analysis for small animal PET imaging
Keywords :
Monte Carlo methods; brain; medical image processing; phantoms; positron emission tomography; workstation clusters; GATE; Monte Carlo simulation; cluster computing architecture; gamma accolinearity effects; maximum a posteriori reconstruction algorithm; microPET FOCUS system; positron range; rat brain dopaminergic studies; realistic [C-11]Raclopride exam; small rodents imaging; voxelized rat brain phantom; Analytical models; Brain modeling; Computational modeling; Computer architecture; Focusing; Imaging phantoms; Monte Carlo methods; Positrons; Reconstruction algorithms; Rodents;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2005 IEEE
Conference_Location :
Fajardo
Print_ISBN :
0-7803-9221-3
DOI :
10.1109/NSSMIC.2005.1596637
