Monte Carlo simulation of the microPET FOCUS system for small rodents imaging applications

Author

Jan, S. ; Desbree, A. ; Pain, F. ; Guez, D. ; Comtat, C. ; Gurden, H. ; Kerhoas, S. ; Lanièce, P. ; Lefebvre, F. ; Mastrippolito, R. ; Trebossen, R.

Author_Institution

Service Hospitalier Frederic Joliot, CEA, Orsay

Volume

3

fYear

2005

fDate

23-29 Oct. 2005

Firstpage

1653

Lastpage

1657

Abstract

In this paper, the authors validated the microPET FOCUS modelling with GATE. The performances of this Monte Carlo platform were presented on voxelized rat brain phantom, specially for the simulation of realistic [C-11]Raclopride exam with a realistic modelling of the injected dose and acquisition time. These results are the consequence of complete installation of this Monte Carlo platform simulation on a cluster computing architecture. Finally, the authors showed a first preliminary approach to improve the quantitative analysis in rat brain dopaminergic studies with an implementation of corrections about the positron range and gamma accolinearity effects. In the future, these corrections could be included as priors in a maximum a posteriori reconstruction algorithm. Moreover, the simulation of whole body exams can be planned in order to optimize the quantitative analysis for small animal PET imaging

Keywords

Monte Carlo methods; brain; medical image processing; phantoms; positron emission tomography; workstation clusters; GATE; Monte Carlo simulation; cluster computing architecture; gamma accolinearity effects; maximum a posteriori reconstruction algorithm; microPET FOCUS system; positron range; rat brain dopaminergic studies; realistic [C-11]Raclopride exam; small rodents imaging; voxelized rat brain phantom; Analytical models; Brain modeling; Computational modeling; Computer architecture; Focusing; Imaging phantoms; Monte Carlo methods; Positrons; Reconstruction algorithms; Rodents;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2005 IEEE

Conference_Location

Fajardo

ISSN

1095-7863

Print_ISBN

0-7803-9221-3

Type

conf

DOI

10.1109/NSSMIC.2005.1596637

Filename

1596637