Title :
Design of logarithmic current amplifier for micro-PCR EC detection
Author :
Guo, Cangran ; Yin, Ming ; Liu, Zewen ; Qing, Jian ; Zhang, Rong
Author_Institution :
Inst. of Microelectron., Tsinghua Univ., Beijing, China
Abstract :
A Logarithmic Current Mode Amplifier (LGCMA) is designed and verified by 0.5 μm process aiming at electrochemical signal detection in the miniaturized polymerase chain reaction (μPCR) chip for the quantitative analysis of deoxyribonucleic acid (DNA) concentration. Fully electronic integrated front end detection system is concepted to readout electrochemical signal using the LGCMA as a pre-amplifier. This paper has a insight to the stability, logarithmic property, bandwidth and dynamic range (DR) and noise level of the LGCMA. The post simulation result shows the operation current ranges six orders of magnitude from 5 pA to 5 μA. Considering that noise presented in the circuits the minimum current resolution is InA.
Keywords :
CMOS analogue integrated circuits; DNA; bioMEMS; current-mode circuits; electrochemical analysis; preamplifiers; signal detection; μPCR chip; CMOS process; DNA concentration; DR; LGCMA; current 1 nA; current 5 pA to 5 muA; deoxyribonucleic acid concentration; dynamic range; electrochemical signal detection; fully electronic integrated front end detection system; logarithmic current mode amplifier; logarithmic property; microPCR EC signal detection; miniaturized polymerase chain reaction chip; minimum current resolution; operation current; preamplifier; quantitative analysis; size 0.5 mum; Current measurement; DNA; Electrodes; Integrated circuit modeling; Noise; Noise level; Simulation; µPCR; electrochemical detection; logarithmic current mode amplifier(LGCMA); minimum current resolution;
Conference_Titel :
Electric Information and Control Engineering (ICEICE), 2011 International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-8036-4
DOI :
10.1109/ICEICE.2011.5778308
