Development of a physiological model forpatients with type 2 diabetes mellitus

Abnormal functioning of different organs such as pancreas, liver and/or body tissues can result in excessive blood glucose concentration in type II diabetic patients. Although a number of models have been developed for evaluating type I diabetes mellitus, there is limited evaluation for patients with type II. This paper presents the development of a model for type II diabetic patients based on a detailed compartmental physiologic model proposed by Sorensen for normal body. The model parameters are estimated using a nonlinear optimization method and frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) data from the literature for type II diabetic patients, the model parameters are optimized for diabetic patients. The proposed model allows further investigation into the dynamic behavior of different organs in type II diabetic patients and how medications may change the course of disease progression.