Development of an immunocompetent human skin tissue model using three dimensional (3D) freeform fabrication

Author

Singh, Gurtej ; Lee, Vivian ; Trasatti, John P. ; Yoo, Seung-Schik ; Dai, Guohao ; Karande, Pankaj

Author_Institution

Chem. & Biol. Eng., Rensselaer Polytech. Inst., Troy, NY, USA

fYear

2011

fDate

1-3 April 2011

Firstpage

1

Lastpage

2

Abstract

We report on the development of a novel in vitro, multi-compartmental, three-dimensional, Human Skin Tissue Experimental Model (HISTEM) using three-dimensional free form fabrication (3DFFF). The availability of this model is expected to positively impact the development of transdermal vaccines and immunomodulators for infectious diseases and autoimmune disorders. Our studies demonstrate the biological and structural equivalence of HISTEM with ex vivo human skin.

Keywords

biomedical engineering; cellular biophysics; diseases; medical disorders; physiological models; skin; autoimmune disorders; cell-printing technology; ex vivo human skin; human skin tissue experimental model; immunocompetent human skin tissue model; infectious diseases; mmunomodulators; three dimensional freeform fabrication; transdermal vaccines; Biological system modeling; Humans; Immune system; In vitro; Printing; Skin; Three dimensional displays;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast

Conference_Location

Troy, NY

ISSN

2160-7001

Print_ISBN

978-1-61284-827-3

Type

conf

DOI

10.1109/NEBC.2011.5778579

Filename

5778579