Title :
An image based system biology approach for Alzheimer´s disease pathway analysis
Author :
Huang, Yue ; Zhou, Xiaobo ; Miao, Benchun ; Lipinski, Marta ; Xia, Zheng ; Hu, Guangshu ; Degterev, Alexei ; Yuan, Junying ; Wong, Stephen T C
Author_Institution :
Dept. of Radiol., Methodist Hosp. Res. Inst., Houston, TX
Abstract :
We report multifactorial analysis of candidate mechanisms of Alzheimer´s disease utilizing high content analysis, gene expression microarray, and linear regression model to integrate neuronal imaging data with hippocampal gene expression data. Our analysis led to the identification of several genes that may contribute to different image traits or phenotypes in the amyloid-beta (Abeta) injured neurons. Gene network and biological pathways analysis for those genes were further analyzed and led to several novel pathways that may contribute to amyloid plaque triggered neurite loss.
Keywords :
diseases; genetics; neurophysiology; regression analysis; Alzheimer´s disease; disease pathway analysis; gene expression microarray; gene network; hippocampal gene expression; linear regression model; neuronal imaging data; system biology; Alzheimer´s disease; Bioinformatics; Biomedical imaging; Gene expression; Genomics; Image analysis; Linear regression; Microscopy; Neurons; Systems biology;
Conference_Titel :
Life Science Systems and Applications Workshop, 2009. LiSSA 2009. IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4244-4292-8
Electronic_ISBN :
978-1-4244-4293-5
DOI :
10.1109/LISSA.2009.4906726
