Mesoscopic fluorescence molecular imaging of tissue engineered vascular construct

In this work, we will report on the design and validation of a Laminar Optical Tomography systems developed at RPI to image tissue-engineered constructs. The systems characteristics and image reconstruction methods will be presented and discussed. In silico and in vitro validation of the imaging platform based on phantom studies mimicking the optical properties of various bio-tissues will demonstrate the potential of the system for tissue engineering applications, especially for imaging thick vascular constructs.