Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration

Author

Tward, D.J. ; Ceritoglu, C. ; Sturgeon, G. ; Segars, William P. ; Miller, M.I. ; Ratnanather, J.T.

Author_Institution

Center for Imaging Sci., Johns Hopkins Univ., Baltimore, MD, USA

fYear

2011

fDate

1-3 April 2011

Firstpage

1

Lastpage

2

Abstract

This work describes a protocol for creating a population of pediatric, patient specific, computational dosimetry phantoms. Pediatric CT data are mapped to a detailed adult template using multi channel (MC) - large deformation diffeomorphic metric mapping (LDDMM) applied to whole body images. Challenges are studied and overcome using 2D LDDMM applied to simulated phantoms. The protocol involves automatic placement of landmarks, landmark based affine and LDDMM registration, followed by 4 applications of MC-LDDMM, with successively decreasing smoothness constraints. Deformed adult organ surfaces typically agree with pediatric organ surfaces within 1-2 voxels (~2.3 mm).

Keywords

biological organs; computerised tomography; dosimetry; image registration; medical image processing; paediatrics; phantoms; 2D LDDMM; LDDMM registration; adult template; computational dosimetry phantoms; deformed adult organ; diffeomorphic image registration; landmark based affine registration; multichannel large deformation diffeomorphic metric mapping; patient-specific dosimetry phantoms; pediatric CT data; pediatric organ surfaces; simulated phantoms; smoothness constraints; whole body images; Computed tomography; Dosimetry; Image registration; Pediatrics; Phantoms; Protocols;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast

Conference_Location

Troy, NY

ISSN

2160-7001

Print_ISBN

978-1-61284-827-3

Type

conf

DOI

10.1109/NEBC.2011.5778717

Filename

5778717