The dependence of contractile force for the cardiomyocytes on a different engineered surface

Author

Kim, Jinseok ; Park, Jungyul ; Cha, Jae Min ; Ryu, Seokchang ; Ryu, Suk Kyu ; Park, Sukho ; Kim, Byungkyu ; Cha, Junghun ; Kim, Hyeon Chul ; Chun, Kukjin

Author_Institution

Microsystem Res. Center, Korea Inst. of Sci. & Technol., Seoul

fYear

2005

fDate

Oct. 30 2005-Nov. 3 2005

Abstract

We present a microfabricated three-dimensional (3-D) hybrid biopolymer microcantilever which can measure the contractile force of cardiomyocytes and analyze the force dependence on different types of surface. To make different conditions of the cell seeding surface, we fabricated the specific type of cantilever which was grooved on the surface. The presented cantilever was facilitated to measure bending of the cantilever and to calculate the contractile force of cardiomyocytes. Also, we demonstrate the dependence of the morphology for the cardiomyocytes seeded on a plain surface and a grooved surface. Finally, we show the dependence of force for the cardiomyocytes on a different surface

Keywords

biological techniques; cantilevers; force sensors; microsensors; 3D hybrid biopolymer microcantilever; bending measurement; cardiomyocytes; cell seeding surface; contractile force; engineered surface; Cardiac arrest; Cardiac disease; Cardiology; Cells (biology); Fabrication; Force measurement; Heart; Muscles; Size measurement; Surface morphology;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2005 IEEE

Conference_Location

Irvine, CA

Print_ISBN

0-7803-9056-3

Type

conf

DOI

10.1109/ICSENS.2005.1597695

Filename

1597695