Title :
The dependence of contractile force for the cardiomyocytes on a different engineered surface
Author :
Kim, Jinseok ; Park, Jungyul ; Cha, Jae Min ; Ryu, Seokchang ; Ryu, Suk Kyu ; Park, Sukho ; Kim, Byungkyu ; Cha, Junghun ; Kim, Hyeon Chul ; Chun, Kukjin
Author_Institution :
Microsystem Res. Center, Korea Inst. of Sci. & Technol., Seoul
fDate :
Oct. 30 2005-Nov. 3 2005
Abstract :
We present a microfabricated three-dimensional (3-D) hybrid biopolymer microcantilever which can measure the contractile force of cardiomyocytes and analyze the force dependence on different types of surface. To make different conditions of the cell seeding surface, we fabricated the specific type of cantilever which was grooved on the surface. The presented cantilever was facilitated to measure bending of the cantilever and to calculate the contractile force of cardiomyocytes. Also, we demonstrate the dependence of the morphology for the cardiomyocytes seeded on a plain surface and a grooved surface. Finally, we show the dependence of force for the cardiomyocytes on a different surface
Keywords :
biological techniques; cantilevers; force sensors; microsensors; 3D hybrid biopolymer microcantilever; bending measurement; cardiomyocytes; cell seeding surface; contractile force; engineered surface; Cardiac arrest; Cardiac disease; Cardiology; Cells (biology); Fabrication; Force measurement; Heart; Muscles; Size measurement; Surface morphology;
Conference_Titel :
Sensors, 2005 IEEE
Conference_Location :
Irvine, CA
Print_ISBN :
0-7803-9056-3
DOI :
10.1109/ICSENS.2005.1597695
