Title :
The application of photocrosslinkable hyaluronan as a corneal perforation sealant
Author :
Grinstaff, Mark W. ; Miki, Ddijiro ; Pfister-Serres, A. ; Dastgheib, Kourosh A. ; Smeds, Kimberly A. ; Inoue, Makoto ; Hatchell, Diane L.
Author_Institution :
Dept. of Chem. & Ophthalmology, Duke Univ., Durham, NC, USA
Abstract :
A novel photocrosslinkable methacrylated hyaluronic acid has been synthesized for use as a corneal perforation sealant. The adhesion strength of this hydrogel to an epithelial surface was quantitated in vitro. In vivo application of this biopolymer sealed 95% of experimental corneal perforations allowing for complete stromal healing and the re-establishment of the cornea
Keywords :
adhesion; biomedical materials; eye; gels; patient treatment; adhesion strength; biopolymer; complete stromal healing; corneal perforation sealant; corneal perforations; epithelial surface; hydrogel; in vitro; in vivo application; photocrosslinkable hyaluronan; photocrosslinkable methacrylated hyaluronic acid; Adhesives; Argon; Cornea; Eyes; In vivo; Polymers; Rabbits; Sealing materials; Testing; Wounds;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803872
