Microtextured membranes promote cardiac myocyte alignment and attachment upon stretching

Author

Deutsch, Jennifer ; Motagh, D. ; Russell, Brenda ; Desai, Tejal

Author_Institution

Dept. of Bioeng., Illinois Univ., Chicago, IL, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Microtextured membranes have been fabricated to provide a transparent biocompatible surface with specific microarchitecture upon which cardiac myocytes exhibit enhanced cellular adhesion due to increased surface area, geometries and attachment points. The microtopography provides anisotropic or directional growth for cells and thus, can recreate tissue architecture at the cellular and subcellular level in a reproducible fashion

Keywords

adhesion; biomechanics; biomedical materials; cardiology; cellular biophysics; membranes; texture; anisotropic growth; attachment point; cardiac myocyte alignment; cardiac myocyte attachment; cellular level; directional growth; enhanced cellular adhesion; geometry; increased surface area; microtextured membranes; microtopography; reproducible fashion; specific microarchitecture; stretching; subcellular level; tissue architecture recreation; transparent biocompatible surface; Adhesives; Biomembranes; Heart; In vitro; In vivo; Microscopy; Pediatrics; Physiology; Proteins; Visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803900

Filename

803900