A model of Lysis of mural platelet-fibrin thrombi

Author

Wootton, D.M. ; Popel, A.S. ; Alevriadou, B.R.

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

Volume

2

fYear

1999

fDate

36434

Abstract

A model of tissue-type plasminogen activator (t-PA) mediated mural clot lysis has been developed. The model treats the clot as a porous two-phase mixture, and includes mechanisms of kinetics and fluid transport of chemical species, and mechanical property degradation as the fibrin dissolves. The model is consistent with experimental lysis of platelet-fibrin substrates in an in vitro whole blood reperfusion model. Lysis time is predicted to decrease with increasing wall shear stress, and increase with increasing plasminogen activator inhibitor (PAI)-1 concentration

Keywords

coagulation; computational fluid dynamics; haemodynamics; haemorheology; physiological models; CFD calculations; blood flow effect; chemical species; fluid transport; in vitro whole blood reperfusion; kinetic mechanisms; mechanical property degradation; model; mural clot lysis; mural platelet-fibrin thrombi; plasminogen activator inhibitor concentration; porous two-phase mixture; tissue-type plasminogen activator mediated; wall shear stress; Degradation; Delay; Equations; In vitro; Inhibitors; Kinetic theory; Mathematical model; Plasma transport processes; Solid modeling; Stress;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803929

Filename

803929