Title :
Acute blood-cellular interaction with textured surfaces
Author :
Fujisawa, N. ; Poole-Warren, L.A. ; Bertram, C.D. ; Odell, R.A. ; Woodard, J.C. ; Schindhelm, K.
Author_Institution :
Graduate Sch. of Biomed. Eng., New South Wales Univ., Sydney, NSW, Australia
Abstract :
A textured blood-contacting surface can promote the formation of a blood-compatible pseudo-neointima. In this study, textured surfaces with three different mat thicknesses were assessed in an ovine ex vivo carotid-jugular series shunt model for periods up to four hours. The results showed that white cell was the predominant cell type deposited. White cell density on the textured base plane was then quantified by image-analysing the electron micrographs of the blood-contacted surfaces. The computational fluid-dynamic (CFD) modelling of the textured surfaces ex vivo revealed that the wall shear stress on the textured base plane was inversely related to the mat thickness. The statistical analysis of cell densities on individual textured surfaces showed effects of wall shear stress, streamwise position, and exposure time
Keywords :
blood; cellular biophysics; surface texture; 4 h; acute blood-cellular interaction; blood-compatible pseudo-neointima formation promotion; blood-contacted surfaces; cell densities statistical analysis; computational fluid-dynamic modelling; electron micrographs image analysis; mat thickness; ovine ex vivo carotid-jugular series shunt model; textured base plane; textured surfaces ex vivo; white cell density; Australia; Biomedical engineering; Blood; Computational fluid dynamics; Electrons; Image sampling; Stress; Surface texture; Surface topography; Testing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803932
