Title :
Position sensing of cells in diagnostic test systems by impedance measurement
Author :
Thielecke, Hagen ; Stieglitz, Thomas ; Ruf, Hans Heinrich
Author_Institution :
Fraunhofer Inst. for Biomed. Eng., St. Ingbert, Germany
Abstract :
In cell-based biosensors which are used in test systems it is advantageous to position cells in array structures. Here, cells are positioned by hydrodynamic flow in microfabricated array structures on suction micro-holes with ring electrodes. The electrode impedance is measured to investigate if the positioning of cells can be electrically monitored. It is shown that hydrodynamic positioning of cells can be monitored by impedance measurement
Keywords :
biocontrol; biosensors; electric impedance measurement; microelectrodes; microfluidics; micropositioning; position measurement; cell-based biosensors; diagnostic test systems; hydrodynamic flow; hydrodynamic positioning; impedance measurement; microfabricated array structures; position sensing of cells; ring electrodes; suction micro-holes; Electrodes; Frequency; Hydrodynamics; Impedance measurement; Monitoring; Position measurement; Sensor arrays; Sensor systems; Substrates; System testing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804004
