DocumentCode :
33056
Title :
Construction and analysis of single nucleotide polymorphism-single nucleotide polymorphism interaction networks
Author :
Yang Liu ; Xutao Li ; Zhiping Liu ; Luonan Chen ; Ng, Michael K.
Author_Institution :
Bioinf. Program, Boston Univ., Boston, MA, USA
Volume :
7
Issue :
5
fYear :
2013
fDate :
Oct-13
Firstpage :
170
Lastpage :
181
Abstract :
The study of gene regulatory network and protein-protein interaction network is believed to be fundamental to the understanding of molecular processes and functions in systems biology. In this study, the authors are interested in single nucleotide polymorphism (SNP) level and construct SNP-SNP interaction network to understand genetic characters and pathogenetic mechanisms of complex diseases. The authors employ existing methods to mine, model and evaluate a SNP sub-network from SNP-SNP interactions. In the study, the authors employ the two SNP datasets: Parkinson disease and coronary artery disease to demonstrate the procedure of construction and analysis of SNP-SNP interaction networks. Experimental results are reported to demonstrate the procedure of construction and analysis of such SNP-SNP interaction networks can recover some existing biological results and related disease genes.
Keywords :
DNA; RNA; biology computing; blood vessels; diseases; genetics; genomics; molecular biophysics; molecular configurations; polymorphism; proteins; Parkinson disease; complex diseases; coronary artery disease; datasets; disease genes; gene regulatory network; genetic characters; molecular processes; pathogenetic mechanisms; protein-protein interaction network; single nucleotide polymorphism interaction networks; systems biology functions;
fLanguage :
English
Journal_Title :
Systems Biology, IET
Publisher :
iet
ISSN :
1751-8849
Type :
jour
DOI :
10.1049/iet-syb.2012.0055
Filename :
6616077
Link To Document :
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