Title :
A physiological simulation model of the glucose-insulin system
Author :
Cobelli, Claudio ; Nucci, Gianluca ; Del Prato, Stefano
Author_Institution :
Dipt. di Elettronica e Inf., Padova Univ., Italy
Abstract :
We have developed a new physiologically based simulation model of the glucose insulin system which describes the main events occurring in a normal life day. The model is based on recent quantitative knowledge that has become available on glucose unit processes during a meal. The model is nonlinear and predicts the time course of glucose and insulin fluxes and pools of a normal subject having breakfast, lunch and dinner. The model provides a realistic framework for examining various facets of the glucoregulatory system and will be the basis for developing a Type I diabetes model
Keywords :
biochemistry; biocontrol; patient care; patient monitoring; physiological models; proteins; Type I diabetes model; breakfast; dinner; glucoregulatory system; glucose unit processes; glucose-insulin system; insulin fluxes; lunch; meal; nonlinear model; normal life day; normal subject; physiological simulation model; time course; Diabetes; Discrete event simulation; Fluids and secretions; Informatics; Insulin; Kinetic theory; Plasma simulation; Production; Standards development; Sugar;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804153
