Title :
A simplified approach to protein folding
Author :
Ruggiero, C. ; Sacile, R.
Author_Institution :
Dept. of Inf. Syst. & Telematics, Genova Univ., Italy
Abstract :
An approach to theoretical calculation of protein three-dimensional structure based on the simplified Levitt´s model is presented. In this model the equilibrium condition is directly reached modifying the molecular structure, taking into account the forces acting on it, rather than minimizing the global energy, Results obtained on PTI show a good representation of its stable native conformation and spontaneous formation of α-helices
Keywords :
molecular biophysics; physiological models; proteins; α-helices; equilibrium condition; molecular structure; protein folding; protein three-dimensional structure; simplified Levitt´s model; spontaneous formation; stable native conformation; theoretical calculation; Bonding forces; Informatics; Mathematical model; Peptides; Proteins; Solid modeling; Solvents; Telematics; Temperature; Testing;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804379
