DocumentCode :
3311476
Title :
Design of insulating devices for in vitro synthetic circuits
Author :
Franco, Elisa ; Vecchio, Domitilla Del ; Murray, Richard M.
Author_Institution :
Div. of Eng. & Appl. Sci., California Inst. of Technol., Pasadena, CA, USA
fYear :
2009
fDate :
15-18 Dec. 2009
Firstpage :
4584
Lastpage :
4589
Abstract :
This paper describes a synthetic in vitro genetic circuit programmed to work as an insulating device. This circuit is composed of nucleic acids, which can be designed to interact according to user defined rules, and of few proteins that perform catalytic functions. A model of the circuit is derived from first principle biochemical laws. This model is shown to exhibit time-scale separation that makes its output insensitive to downstream time varying loads. Simulation results show the circuit effectiveness and represent the starting point for future experimental testing of the device.
Keywords :
biochemistry; genetics; insulating materials; proteins; catalytic functions; first principle biochemical laws; in vitro synthetic circuits; insulating devices; nucleic acids; proteins; Circuit testing; DNA; Genetics; In vitro; Insulation; Integrated circuit interconnections; Nanobioscience; Oscillators; Protein engineering; Signal design;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Decision and Control, 2009 held jointly with the 2009 28th Chinese Control Conference. CDC/CCC 2009. Proceedings of the 48th IEEE Conference on
Conference_Location :
Shanghai
ISSN :
0191-2216
Print_ISBN :
978-1-4244-3871-6
Electronic_ISBN :
0191-2216
Type :
conf
DOI :
10.1109/CDC.2009.5400523
Filename :
5400523
Link To Document :
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