Cellular Automata Model of Protein Adsorption on the Surface of Bioceramics

Author

Wang, Huimin ; Nie, Guihua ; Fu, Kui

Author_Institution

Sch. of Econ., Wuhan Univ. of Technol., Wuhan

Volume

7

fYear

2008

fDate

18-20 Oct. 2008

Firstpage

417

Lastpage

420

Abstract

Calcium phosphate bioceramics are used widely as bone scaffold materials. To understand the process of protein adsorption on the surface of bioceramics, in the paper a Cellular Automata model is provided to simulate it. The model is concerned with the study of two-dimensional protein adsorption, considering the pore size, interconnectivity and the adsorption probability and desorption probability of proteins. Three simulation steps focusing on porous structures, body fluid flow in porous bioceramics and protein adsorption on the surface of bioceramics are discussed. The simulation results show the curves of proteins adsorbed on the surface of bioceramics vs. time are coincident with the results of the experiments in vitro.

Keywords

adsorption; bioceramics; bone; calcium compounds; cellular automata; desorption; porous materials; proteins; adsorption probability; body fluid flow; bone scaffold materials; calcium phosphate bioceramics; cellular automata model; desorption probability; pore size; porous bioceramics; porous structures; protein adsorption; protein interconnectivity; Bioceramics; Biological materials; Bones; Calcium; Computational modeling; Computer simulation; Degradation; Fluid flow; Proteins; Random number generation; Cellular Automata; Computer simulation; protein adsorption;

fLanguage

English

Publisher

ieee

Conference_Titel

Natural Computation, 2008. ICNC '08. Fourth International Conference on

Conference_Location

Jinan

Print_ISBN

978-0-7695-3304-9

Type

conf

DOI

10.1109/ICNC.2008.611

Filename

4668011