Title :
Fabrication of a tissue-equivalent cardiovascular valve
Author :
Neidert, M.R. ; Tower, T.T. ; Oegema, T.R. ; Tranquillo, R.T.
Author_Institution :
Dept. of Chem. Eng., Minnesota Univ., Minneapolis, MN, USA
Abstract :
Describes a mold to fabricate multileaflet “valve-equivalents” based on the tissue-equivalent approach of entrapping tissue cells in a self-assembled biopolymer scaffold which the cells compact. The mold design results in leaflet structures possessing circumferential alignment characteristic of native leaflets. The authors report on the geometry, alignment, and mechanical properties for the valve-equivalent leaflets
Keywords :
biological tissues; biomechanics; cardiology; cellular biophysics; mechanical properties; prosthetics; bioprosthesis; bovine dermal collagen; circumferential alignment; leaflet structures; mold design; native leaflets; self-assembled biopolymer scaffold; tissue cells entrapping; tissue-equivalent cardiovascular valve fabrication; valve-equivalent leaflets; Cardiac disease; Cardiology; Cardiovascular diseases; Compaction; Fabrication; Plugs; Poles and towers; Roentgenium; Valves;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804503
