Title :
Integrative modeling of cardiac arrhythmia: relating gene expression to cell and tissue function
Author :
Winslow, Raimond L.
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
The development and analysis of biophysically and anatomically detailed computational models of physiological systems is beginning to provide an important tool for relating changes in gene expression to changes in biological function at the levels of cell and tissue in both health and disease. The authors illustrate this approach using computational models of the failing heart developed recently within their laboratory
Keywords :
biological tissues; cardiology; cellular biophysics; diseases; genetics; physiological models; anatomically detailed computational models; biophysically detailed computational models; cardiac arrhythmia; cell function; failing heart; gene expression; health; integrative modeling; physiological systems; tissue function; Biological system modeling; Biology computing; Biomedical computing; Cardiac disease; Cardiovascular diseases; Cells (biology); Computational modeling; Gene expression; Heart; Medical diagnostic imaging;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804507
