Title :
Reconstructing genetic regulation network: Problems and methods
Author :
Han, Zhongming ; Dagao Duan ; Li, Dagao Duan Wenzheng ; Liu, Hongzhi
Author_Institution :
Sch. of Comput. Sci. & Inf. Eng., Beijing Technol. & Bus. Univ., Beijing, China
Abstract :
Understanding regulation mechanism of gene expression is the kernel of system biology. Reconstructing genetic regulation network from real gene expression microarray data has draw a lot of attention. Two basic problems for reconstructing genetic regulation network: the network topology and reconstructing method are detailed discussed in this paper. Some possible improved algorithms are proposed.
Keywords :
biology; data analysis; genetic algorithms; genetic regulation network reconstruction; network topology; real gene expression microarray data; regulation mechanism; system biology kernel; Bayesian methods; Biological system modeling; Cells (biology); Clustering algorithms; Computer science; Gene expression; Genetic engineering; Kernel; Matrix decomposition; Systems biology; Gene Regulation network; Reconstruct;
Conference_Titel :
Computer Science and Information Technology, 2009. ICCSIT 2009. 2nd IEEE International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-4519-6
Electronic_ISBN :
978-1-4244-4520-2
DOI :
10.1109/ICCSIT.2009.5234743
