DocumentCode
3317750
Title
Notice of Retraction
Molecular Cloning and Sequence Analysis of the Gene Encoding Interleukin-18 of the Giant Panda (Ailuropoda melanoleuca)
Author
Feng Gu ; Chengdong Wang ; Desheng Li ; Ling Zhu ; Fengqin Li ; Yue Yi ; Zhiwen Xu ; Wanzhu Guo
Author_Institution
Animal Biotechnol. Center, Sichuan Agric. Univ., Yaan, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
5
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Interleukin-18 (IL-18) is a novel proinflammatory cytokine with potent interferon (IFN)-γ inducing activity that plays a crucial biological role in the enhancement of the activity of natural killer cells and cytotoxic T lymphocytes. In the present study, the cloning and sequence analysis of interleukin-18 (IL-18) from the giant panda (Ailuropoda melanoleuca) were described. The results showed that the cloned giant panda IL-18 gene was 582 bp in length, encoding a polypeptide of 192 amino acids. Homology analyses indicated that the identity levels of nucleotide and deduced that amino and acid sequences of IL-18 between the giant panda and other species of mammals ranges from 98.6% to 82.5% and from 96.4% to 73.2%, respectively. The functionally important domains and sites that have previously been recognized in other mammals were all observed in the IL-18 sequence of the giant panda. These result proves that the cDNA fragment cloned is indeed the IL-18 molecule with biological activity and can be used in immunological studies of the giant panda.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Interleukin-18 (IL-18) is a novel proinflammatory cytokine with potent interferon (IFN)-γ inducing activity that plays a crucial biological role in the enhancement of the activity of natural killer cells and cytotoxic T lymphocytes. In the present study, the cloning and sequence analysis of interleukin-18 (IL-18) from the giant panda (Ailuropoda melanoleuca) were described. The results showed that the cloned giant panda IL-18 gene was 582 bp in length, encoding a polypeptide of 192 amino acids. Homology analyses indicated that the identity levels of nucleotide and deduced that amino and acid sequences of IL-18 between the giant panda and other species of mammals ranges from 98.6% to 82.5% and from 96.4% to 73.2%, respectively. The functionally important domains and sites that have previously been recognized in other mammals were all observed in the IL-18 sequence of the giant panda. These result proves that the cDNA fragment cloned is indeed the IL-18 molecule with biological activity and can be used in immunological studies of the giant panda.
Keywords
biology computing; cellular biophysics; encoding; genetics; molecular biophysics; proteins; zoology; Ailuropoda melanoleuca; IL-18; amino acid polypeptide; cDNA fragment; cytotoxic T lymphocytes; gene encoding; giant panda; interleukin-18; killer cells; molecular cloning; potent interferon-γ; proinflammatory cytokine; sequence analysis; Amino acids; Cloning; Diseases; Humans; Immune system; Proteins; RNA;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780017
Filename
5780017
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