Notice of RetractionThe Oxidative Stress and DNA Damage of Blood Cells Induced by Exercise Fatigue

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

To discuss the effect of DNA damage and its mechanism on blood cells induced by exercise fatigue. 24 male Kunming mice were randomized into four groups: control group (CG) and exercise group (EG) was subdivided to three subgroups respectively indicating as 0EG, 24EG, 48EG (N=6/group). We built up the exercise fatigue model for mice through the protocol of repeated exhaustive treadmill running and use the single cell gel electrophoresis (SCGE) to detect the DNA damage of blood cells in different groups. We also measured the changes of SOD, GSH and MDA in plasma. Our studies showed that DNA damage of OEG and 24EG were significantly higher than CG. DNA damage reached the highest at 24h and dropped to the pre-exercise level at 48h. The activity of SOD and the content of MDA in plasma of OEG and 24EG significantly increased compared with CG. Those changes in 24EG significantly decreased compared with OEG. GSH concentration in OEG reduced significantly compared with CG. Either the 24EG or 48EG of GSH did not change obviously compared with CG. Those results have leaded to conclusions that exercise fatigue can induce the oxidative injury and DNA damage on blood cells which exists some characters in different time after exercise. Exercise induced oxidative stress is one of the mechanism of DNA damage on blood cells.