Title :
Short- and long-term adaptation in olfactory transduction as a leaky integral feedback
Author :
De Palo, G. ; Boccaccio, A. ; Menini, A. ; Altafini, C.
Author_Institution :
SISSA-ISAS Int. Sch. for Adv. Studies, Trieste, Italy
Abstract :
Complex sensory systems such as the olfactory transduction pathway considered in this paper are known to exhibit two distinct types of adaptation: long term adaptation in response to step-like stimulations and short-term adaptation in response to sequences of pulse-like stimuli. We show in this paper that perfect adaptation models such as the integral feedback scheme are unable to explain both these phenomena simultaneously, but that a leaky integral feedback (i.e., a dynamical compensator including also a slow degradation term) reproduces well all experimental data available.
Keywords :
biology; chemioception; feedback; integral equations; large-scale systems; complex sensory systems; integral feedback scheme; leaky integral feedback; long term adaptation; olfactory transduction pathway; pulse-like stimuli sequence; short term adaptation; Adaptation model; Biological system modeling; Biological systems; Biomembranes; Calcium; Degradation; Negative feedback; Neurons; Olfactory; Pulse measurements;
Conference_Titel :
Decision and Control, 2009 held jointly with the 2009 28th Chinese Control Conference. CDC/CCC 2009. Proceedings of the 48th IEEE Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-3871-6
Electronic_ISBN :
0191-2216
DOI :
10.1109/CDC.2009.5400910