Title :
Effect of high intensity focused ultrasound on intracellular signaling in rat liver
Author :
Zaitsev, A.V. ; Sanghvi, N.T. ; Jin, N. ; Hatton, N.B. ; Rhoades, R.A.
Author_Institution :
ICFAR, Indiana Univ., Indianapolis, IN, USA
Abstract :
High Intensity Focused Ultrasound (HIFU) can be used as a minimal invasive therapeutic modality for ablating diseased tissue. The objective of the present investigation was to determine the effect of of HIFU treatment on adjacent tissue of the treatment zone (i.e., tissue in the near field of the HIFU beam). Activity of mitogen activated protein (MAP) kinase and protein kinase C (PKC), and expression of early response gene (c-jun) were chosen to investigate changes in intracellular signalling in rat liver following HIFU treatment
Keywords :
biological effects of acoustic radiation; biomedical ultrasonics; cellular effects of radiation; liver; ultrasonic effects; c-jun; diseased tissue ablation; early response gene expression; high intensity focused ultrasound effect; intracellular signaling; minimal invasive therapeutic modality; mitogen activated protein kinase activity; protein kinase C; rat liver; tissue adjacent to treatment zone; Animals; Biochemistry; Biological materials; Biomembranes; Liver; Probes; Proteins; Radio access networks; Surgery; Ultrasonic imaging;
Conference_Titel :
Ultrasonics Symposium, 1997. Proceedings., 1997 IEEE
Conference_Location :
Toronto, Ont.
Print_ISBN :
0-7803-4153-8
DOI :
10.1109/ULTSYM.1997.661831
