Physiological Modelling and Multivariable SOFLC of Drug Administration for Critically III Patients

A compartmental model is modified to simulate the capillary leak associated with sepsis and cardiopulmonary bypass (CPB). Sepsis refers to a systemic inflammatory response to bacterial infection. This involves continuously updating the oncotic pressures with regard to the flows in and out of each compartment. As a result, it is possible to model the effects of administering fluids with different oncotic pressures on filtration. The model allows for simulated infusions of vasoactive and inotropic drugs with a range of sensitivities to these drugs, giving a comprehensive platform for testing various control strategies. Furthermore, self-organising fuzzy logic control (SOFLC), drug sensitivity estimation, linear decoupling and noise filtering were used to control this system in a multivariable control scheme.