DocumentCode
3318821
Title
Notice of Retraction
Visualization and Analysis of Integrin Signaling Network
Author
Xiao-Lan Wei
Author_Institution
Coll. of Environ. & Biol. Eng., Chongqing Technol. & Bus. Univ., Chongqing, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Integrins are bidirectional signaling and adhesion receptors that not only act as both antennas and receptors but also influence fundamental cell biological processes ranging from development to disease. Their ability to convert mechanical and chemical information from inside and outside the cell rests on the function of the complex signaling network. Here, the integrin signaling network is constructed and visualized, in which 156 components are linked by 690 interactions with an average node degree of 8.66, cluster coefficient of 0.24 and path length of 2.6. Several functional modules are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Screening and examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by 3-nodes (three-component complexes). The results will be of potentials for specific targeting, which are desirable in cell, disease diagnosis and therapy, and drug discovery.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Integrins are bidirectional signaling and adhesion receptors that not only act as both antennas and receptors but also influence fundamental cell biological processes ranging from development to disease. Their ability to convert mechanical and chemical information from inside and outside the cell rests on the function of the complex signaling network. Here, the integrin signaling network is constructed and visualized, in which 156 components are linked by 690 interactions with an average node degree of 8.66, cluster coefficient of 0.24 and path length of 2.6. Several functional modules are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Screening and examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by 3-nodes (three-component complexes). The results will be of potentials for specific targeting, which are desirable in cell, disease diagnosis and therapy, and drug discovery.
Keywords
biochemistry; biology computing; biomechanics; bone; cell motility; data mining; data visualisation; diseases; enzymes; molecular biophysics; proteins; adhesion receptors; bidirectional signaling; biological processes; cell adhesion; chemical information; cytoskeletal organization; data mining; disease diagnosis; disease therapy; drug discovery; integrin signaling network; mechanical information; Adhesives; Lipidomics; Proteins; Regulators; Substrates;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780095
Filename
5780095
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