Notice of RetractionProtein Phosphorylation of NRF1 Is Influenced by MCRS2

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Nrf1 [p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1], a member of the CNC bZIP (CNC basic region leucine zipper) family, is known to be a transcriptional activator by dimerization with its distinct partners, such as Maf, FosB, c-Jun, JunD, etc. The transcriptional roles of CNC-bZIP family are demonstrated to be involved in globin gene expression as well as the antioxidant response. MCRS2, a protein with transforming, nucleolar sequestration, ribosomal gene regulation, as well as telomerase inhibition activities, was identified as a novel interacting protein of Nrf1. In this study, we find that ERK1/2 phosphorylates Nrf1 during the interaction between Nrf1 and MCRS2. The phosphorylation of Nrf1 is induced by MCRS2 among the interactions between MCRS2 and Nrf1.