DocumentCode
3319215
Title
Notice of Retraction
A Cluster of Five Hydroxysteroid Dehydrogenase Genes Belonging to the Aldo-Keto Reductase Supergene Family on Human Chromosome 10
Author
Moli Huang ; Hairong Duan
Author_Institution
Center for Syst. Biol., Soochow Univ., Suzhou, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
3
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Over recent years, much attentions have focused on the hydroxysteroid dehydrogenases (HSD) subfamily members belonging to the aldo-keto reductase (AKR) 1C subfamily (AKR1C). This is due to the ability of AKR1C enzymes to modify androgens, estrogens, progesterone and prostaglandins (PGs) in a tissue-specific manner, regulating the activity of nuclear receptors and other downstream effects. In the study, we describe a cluster of the HSDs gene family on human chromosome 10. These include four previously reported human HSD genes (AKR1-C1, -C2, -C3, and AKR1-C4) and a more distantly related AKR1E2. We also compared the five human and the ninty murine isoforms in their phylogeny. Our results demonstrate that at least AKR1E2 should reside in the AKR gene cluster and was clearly the most divergent of the four AKR1C proteins.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Over recent years, much attentions have focused on the hydroxysteroid dehydrogenases (HSD) subfamily members belonging to the aldo-keto reductase (AKR) 1C subfamily (AKR1C). This is due to the ability of AKR1C enzymes to modify androgens, estrogens, progesterone and prostaglandins (PGs) in a tissue-specific manner, regulating the activity of nuclear receptors and other downstream effects. In the study, we describe a cluster of the HSDs gene family on human chromosome 10. These include four previously reported human HSD genes (AKR1-C1, -C2, -C3, and AKR1-C4) and a more distantly related AKR1E2. We also compared the five human and the ninty murine isoforms in their phylogeny. Our results demonstrate that at least AKR1E2 should reside in the AKR gene cluster and was clearly the most divergent of the four AKR1C proteins.
Keywords
bioinformatics; enzymes; evolution (biological); genetics; molecular biophysics; molecular configurations; aldo-keto reductase supergene family; androgens; downstream effects; enzymes; estrogens; human chromosome 10; hydroxy steroid dehydrogenase genes; nuclear receptors; phylogeny; progesterone; prostaglandins; proteins; Amino acids; Bioinformatics; Biological cells; Genomics; Humans; Phylogeny; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780120
Filename
5780120
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