Notice of RetractionFabrication of Injectable PLLA/Alginate Hydrogel for Tissue Engineering

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Alginate, with the prosperities of easy gelation, good biocompatibility, lower toxicity, etc, is a kind of ideal materials to prepare injectable hydrogel. However, the use of alginate hydrogel in tissue engineering and control drug release applications is limited by the weak mechanical properties and the poor loading of hydrophobic components. In the present study, a kind of injectable PLLA/alginate calcium composite hydrogel system, containing different content of PLLA microspheres, had been successfully built by the method of in-situ release and transformation. In this system, the compressive strength increased by 30.9% through the introduction of PLLA microspheres to alginate calcium hydrogel. In addition, the hydrophobicity of PLLA can reduce the water absorption of alginate hydrogel; therefore, the addition of PLLA microspheres had a positive effect on the maintenance of alginate hydrogel´s mechanical strength, which could enlarge the field that alginate hydrogel can be utilized. PLLA microspheres in this composite hydrogel could also be used as hydrophobic drugs delivery vehicles. In this way, new functions were introduced to this system and the injectabililty of the composite hydrogel was guaranteed as well.