Title :
Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy
Author :
Kaddi, Chanchala D. ; Wang, May Dongmei
Author_Institution :
Dept. of Biomed. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination effects of cooperation and drug treatment qualitatively match experimental observations from the literature.
Keywords :
cancer; cellular biophysics; drugs; medical computing; multi-agent systems; Lotka-Volterra competition; agent-based model; cancer; cooperative behavior model; cytotoxic drug treatment; drug resistance; drug therapy; drug treatment; head cancer cell population dynamics; individual cancer cells; intercellular cooperative interactions; mathematical model; neck cancer cell population dynamics; Cancer; Drugs; Mathematical model; Neck; Protocols; Sociology; Statistics;
Conference_Titel :
Biomedical Sciences and Engineering Conference (BSEC), 2013
Conference_Location :
Oak Ridge, TN
Print_ISBN :
978-1-4799-2118-8
DOI :
10.1109/BSEC.2013.6618486
