Notice of RetractionAn Alternative Sustained Release Microsphere of Silk Fibroin-Chitosan: Preparation, Pharmaceutical Characteristics and Pharmacokinetic Profiles

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

The silk fibroin-chitosan loaded diclofenac sodium microspheres (DS-SF/CS-MS) were prepared with an emulsion crosslinking technique. The loading drug content and encapsulated efficiency of the obtained microspheres were (9.88±0.49)% and (50.35±0.92)%, respectively, with the average diameter was about (26.54±1.39)μm. The release profile of DS-SF/CS-MS was fitting to Higuchi´s equation in PBS pH from 5.8 to 7.4. The plasma concentration versus time curve was coincident with one compartment model and the pharmacokinetics parameters were calculated by 3P97 program. The relative bioavailability of DS-CS-MS is 140.0% comparing to diclofenac sodium, together with SF/CS-MS, was a potential novel sustained-release carrier material with low toxicity due to its novel performance.