Title :
Notice of Retraction
Docetaxel-Loaded TPGS-b-(PLA-ran-PGA) Nanoparticles for Cervix Cancer Treatment
Author :
Yi Zheng ; Laiqiang Huang ; Lin Mei
Author_Institution :
Shenzhen Key Lab. of Gene & Antibody Therapy, Tsinghua Univ., Shenzhen, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
A novel biodegradable TPGS-b-(PLA-ran-PGA) diblock copolymer was synthesized and characterized. The docetaxel-loaded TPGS-b-(PLA-ran-PGA) nanoparticles copolymer were then prepared and characterized. The results showed that the particle size of TPGS-b-(PLA-ran-PGA) nanoparticles was around 250 nm. The docetaxel-loaded TPGS-b-(PLA-ran-PGA) nanoparticles could achieve much faster drug release in comparison with PLGA nanoparticles. In vitro cellular uptakes of such nanoparticles were investigated by CLSM, demonstrating the fluorescence TPGS-b-(PLA-ran-PGA) nanoparticles could be internalized by HeLa cells. The results also indicated that TPGS-b-(PLA-ran-PGA) nanoparticles were biocompatible, and the docetaxel-loaded TPGS-b-(PLA-ran-PGA) nanoparticles had significant cytotoxicity against Hela cells. The cytotoxicity against HeLa cells for TPGS-b-(PLA-ran-PGA) nanoparticles was in time- and concentration-dependent manner. In conclusion, TPGS-b-(PLA-ran-PGA) copolymer could be acted as a potential biocompatible polymeric matrix material applicable to nanoparticle-based drug delivery system for cancer chemotherapy.
Keywords :
biomedical materials; cancer; cellular biophysics; drug delivery systems; drugs; gynaecology; materials preparation; nanomedicine; nanoparticles; polymer blends; CLSM; HeLa cells; TPGS-b-(PLA-ran-PGA) diblock copolymer; biocompatible nanoparticles; biocompatible polymeric matrix material; biodegradable diblock copolymer; cancer chemotherapy; cervical cancer treatment; cytotoxicity; diblock copolymer characterisation; diblock copolymer synthesis; docetaxel loaded TPGS-b-(PLA-ran-PGA) nanoparticles; drug release; in vitro cellular uptake; nanoparticle based drug delivery system; Cancer; Drug delivery; Drugs; Electronics packaging; In vitro; Loading; Nanoparticles;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5780321
