Notice of RetractionProtective Effects of Cartilage Polysaccharide against Atrophy of Thymus in Murine H22 Hepatocarcinoma Bearing Mice

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Degeneration of thymus would obstruct T cell proliferation, differentiation and maturation. In our previous studys, we had shown that cartilage polysaccharide had a remarkable antitumor effect on H22 Hepatocarcinoma tmuor bearing mice. In this article, we attempted to reveal that cartilage polysaccharide might protect thymus from atrophy. After four weeks of implantation of H22 Hepatocarcinoma cells, there was an extreme thymic atrophy in the host. However, we found that the thymuses of H22 Hepatocarcinoma tumor bearing mice injected with cartilage polysaccharide 30mg/d didn´t involve in thymic atrophy. We measured the weight and size of the thymuses to show the protective effect of central lymphoid system by utilization of cartilage polysaccharide, and illustrated the thymic architecture changes by H-E staining. Besides, we found apoptosis on the thymus of H22 Hepatocarcinoma tumor bearing mice, and cartilage polysaccharide had a notable protection against thymic apoptosis in H22 Hepatocarcinoma tumor bearers.