Notice of RetractionAnalysis of the Properties of Transdermal Drug Delivery with Constant Surface Drug Concentration

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

Objective: To build a mathematical model of percutaneous drug delivery, then solve it with appropriate initial conditions and boundary conditions to get the concentration profile of drugs in the skin. Methods: Based on the three-step percutaneous penetration model and Fick´s law of diffusion, build a mathematical model, analyze the factors which affect the process of diffusion. Results: By mathematical analysis, we get the drug concentration profiles in the skin layer at different time and the characteristic curves of drug penetration performance. Diffusion and absorption properties of drug under different surface drug concentration and diffusion coefficients are also given. Conclusion: Increasing the diffusion coefficient within a certain range can effectively accelerate the drug diffusion and absorption. Surface drug concentration has a small impact on the diffusion rate, but it can significantly promote the absorption process in subcutaneous tissue. Therefore, appropriately increasing skin diffusion coefficient and surface drug concentration is the main purpose of different enhancing osmosis methods.