Notice of RetractionEffect of Endotoxin on Acute Renal Failure Induced by High-Dose Cisplatin in Rats

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

[Objective] To study the relationship between plasma endotoxin and renal function in acute renal failure induced by high dose cisplatin (DDP) in rats. [Method] 36 SD rats were divided randomly into 6 groups: DDP 6 h, DDP 48 h, DDP control, normal saline (NS) 6 h, 48 h and NS control group ( n = 6 in each group). 10 mg/kg DDP was injected intraperitoneally while same volume of natural saline was given as the control. Toxic effects of DDP were observed subsequently. Heparinized blood samples were obtained by heart punctures 6 h and 48 h after DDP and NS administration and plasma endotoxin was measured by using the BET-16 bacterium endotoxin cryoscope. At the same time blood samples were obtained from orbital venous sinus and blood urea nitrogen (BUN) and creatinine (Cre) were measured by automatic biochemistry analyzer. [Result] Body weight of the rats decreased significantly at 6 h after DDP administration; diarrhea increased progressively at 48 h after DDP administration and the rats died in 3 d. There were no significant differences in blood BUN and creatinine between cisplatin group and control group 6 hours after administrations (P >;0.05); Blood BUN and Cre increased to (18.71 ±9.9) mmol/L and (49.6±14.1) μmol/L respectively in rats 48 h after DDP administrations, significantly higher than the (7.48 ±0.6) mmol/L and (27.17±1.7) μmol/L in control group (P<;0.05). Plasma endotoxin decreased below the detection limit of 0.0218 Eu/ml 6 h after DDP administra- ion, significantly lower than the (0.3141±0.1477) Eu/ml in control group (P<;0.01), while it increased above the detection limit of 0.70 Eu/ml 48 h after DDP administration, obviously higher than the (0.1661 ±0.1198) Eu/ml in control group ( P<;0.01). [Conclusion] Although there was no positive correlation between plasma endotoxin and renal injure in 6 h after DDP administration, the increase of plasma endotoxin may be an important - athophysiological factor of cisplatin-induced nephrotoxicity.