Title :
Measurements of [11C]CO2 in exhaled air with a positron-sensitive single-wire proportional counter after i.v. injection of [11C]acetate
Author :
Sipila, Hannu T. ; Heselius, Sven-Johan ; Kalliokoski, Matti K. ; Kemppainen, Jukka ; Minn, Heikki ; Tolvanen, Tuula ; Roivainen, Anne
Author_Institution :
Turku PET Centre, Turku Univ. Hosp., Turku, Finland
Abstract :
A positron-sensitive, large-window single-wire proportional counter was used for measurements of [11C]CO2 in exhaled air after i.v. injection of [11C]acetate. The performance of the proportional counter was studied using Geant4 and Garfield simulation tools as well as experimentally by injections of known amounts of radioactive gas into the measuring volume. The proportional counter was found to be sensitive enough for measuring the low concentrations of [11C]CO2 in the air exhaled by patients after i.v. injection of an 11C-labelled radiopharmaceutical. The limit of detection was 200 Bq/L for [11C]CO2.
Keywords :
biochemistry; biomedical measurement; chemical variables measurement; organic compounds; pneumodynamics; positron emission tomography; proportional counters; CO2; Garfield simulation; Geant4 simulation; acetate; carbon dioxide measurement; exhaled air; positron sensitive single wire proportional counter; radioactive gas; radiopharmaceutical; Heating;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE
Conference_Location :
Valencia
Print_ISBN :
978-1-4673-0118-3
DOI :
10.1109/NSSMIC.2011.6152653
