Preparation of Fast-Dissolving Ursolic Acid Nanofiber Membrances Using Electrospinning

Author

Huang, Li-ya ; Yu, Deng-Guang ; Zhu, Li-Min ; Branford-White, Christopher J. ; White, Kenneth

Author_Institution

Coll. of Chem., Chem. Eng. & Biotechnol., Donghua Univ., Shanghai, China

fYear

2011

fDate

10-12 May 2011

Firstpage

1

Lastpage

4

Abstract

A composite nanofiber mat composed of a filament-forming polymer matrix and a traditional Chinese medicine Ursolic Acid (UA) has been successfully prepared using electro-spinning process in the present study. Poly-vinyl-pyrrolidone K30 (PVP) was used as hydrophilic carrier to fabricate the nanofibers and improve the dissolution property of UA. The morphologies of the resultant nanofibers were evaluated using Field-emission scanning electron microscopy (FESEM). The results demonstrated that the composite mat with a UA: PVP weight ratio of 1:4 had smooth surface, small diameter and structural uniformity. The in vitro dissolution tests indicated that electrospun nanofibers exhibited the fastest release profiles compared to those of pure UA and UA-PVP physical mixtures. Electrospun nanofibers have the potential to be developed as fast-dissolving drug delivery systems for Traditional Chinese Medicine.

Keywords

biomembranes; cellular biophysics; composite materials; dissolving; drug delivery systems; electrospinning; field emission electron microscopy; hydrophilicity; mixtures; nanobiotechnology; nanofibres; organic compounds; FESEM; composite nanofiber mat; electrospinning; electrospun nanofibers; fast-dissolving drug delivery systems; fast-dissolving ursolic acid nanofiber membranes; field-emission scanning electron microscopy; filament-forming polymer matrix; hydrophilic carrier; in vitro dissolution testing; physical mixtures; poly-vinyl-pyrrolidone K30; structural uniformity; traditional chinese medicine; Drug delivery; Drugs; Electric potential; In vitro; Media; Polymers; Scanning electron microscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on

Conference_Location

Wuhan

ISSN

2151-7614

Print_ISBN

978-1-4244-5088-6

Type

conf

DOI

10.1109/icbbe.2011.5780692

Filename

5780692