DocumentCode :
3330979
Title :
Towards quantification of dedicated breast SPECT using non-traditional acquisition trajectories
Author :
Perez, Kristy L. ; Cutler, Spencer J. ; Madhav, Priti ; Tornai, Martin P.
Author_Institution :
Med. Phys. Program & Radiol. Dept., Duke Univ., Durham, NC, USA
fYear :
2009
fDate :
Oct. 24 2009-Nov. 1 2009
Firstpage :
3866
Lastpage :
3870
Abstract :
Quantification of radiotracer uptake in lesions can provide valuable information to physicians in deciding patient care or determining treatment efficacy. Physical processes (e.g. scatter, attenuation), detector/collimator characteristics, sampling and acquisition trajectories, and reconstruction artifacts contribute to an incorrect absolute measurement of tracer activity and distribution. For these experiments, a cylinder with three syringes of varying radioactivity concentration, and a fillable 800 mL breast with two lesion phantoms containing aqueous 99mTc pertechnetate were imaged using the SPECT subsystem of the dual-modality SPECT-CT dedicated breast scanner. SPECT images were collected using a compact CZT camera with various 3D acquisitions including vertical axis of rotation, 30° tilted, and complex sinusoidal trajectories. Quantitative differences in the measured absolute activity values were investigated for each acquisition trajectory to determine the efficacy of an acquisition trajectory to quantify regions of focal uptake. With attenuation and scatter corrections applied, reconstruction image results showed that the measured average activity concentrations in the hot-spot areas corresponded to within 15% of the actual dose calibrator measured activity concentration. More complete sampling trajectories outperform incomplete tilted acquisition trajectories.
Keywords :
biological organs; dosimetry; image reconstruction; medical image processing; phantoms; single photon emission computed tomography; 99mTc pertechnetate; SPECT; activity concentrations; attenuation corrections; compact CZT camera; dose calibrator; dual-modality SPECT-CT dedicated breast scanner; hot-spot areas; image reconstruction; incomplete tilted acquisition trajectories; lesion phantoms; radioactivity; radiotracer uptake; sampling trajectories; scatter corrections; Area measurement; Attenuation measurement; Breast; Collimators; Detectors; Image reconstruction; Image sampling; Lesions; Medical treatment; Scattering;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium Conference Record (NSS/MIC), 2009 IEEE
Conference_Location :
Orlando, FL
ISSN :
1095-7863
Print_ISBN :
978-1-4244-3961-4
Electronic_ISBN :
1095-7863
Type :
conf
DOI :
10.1109/NSSMIC.2009.5401917
Filename :
5401917
Link To Document :
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