Enhanced skeletal muscle healing and regeneration by purified novel mitogen(s) from rat

Author

Li, M. ; Jiao, Z.X. ; Cai, D.Q. ; Lee, K.H. ; Liu, M.J. ; Chan, K.M.

Author_Institution

Dept. of Orthopaedics & Trauma., Chinese Univ. of Hong Kong, Shatin, Hong Kong

Volume

5

fYear

1998

fDate

28 Oct-1 Nov 1998

Firstpage

2764

Abstract

Two satellite cell specific myogenic factors (mitogens) have been partially identified and purified from skeletal red muscle of adult rats. These two partially purified mitogens could synergically and significantly trigger the proliferation and differentiation of autogenous satellite cells whose progeny subsequently fuse to pre-existing partially damaged muscle fibers to form full repair of the damaged muscle fibers or to form new myotubes to replace the completely damaged muscle fibers during the cascade of muscle healing and regeneration in vivo

Keywords

biochemistry; cellular biophysics; muscle; patient treatment; adult rats; autogenous satellite cells; differentiation; enhanced skeletal muscle healing; muscle regeneration; myogenesis; myotubes; partially purified mitogens; proliferation; purified novel mitogens; satellite cell specific myogenic factors; skeletal red muscle; Drugs; Embryo; Fuses; In vivo; Injuries; Muscles; Orthopedic surgery; Rats; Recruitment; Satellites;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE

Conference_Location

Hong Kong

ISSN

1094-687X

Print_ISBN

0-7803-5164-9

Type

conf

DOI

10.1109/IEMBS.1998.745251

Filename

745251