Microfluidic chamber array for generating concentration gradients

Author

Yamada, Masumi ; Seki, Minoru

Author_Institution

Dept. of Chem. & Biotechnol., Univ. of Tokyo, Japan

fYear

2003

fDate

19-23 Jan. 2003

Firstpage

347

Lastpage

350

Abstract

A novel microfluidic chamber array system has been developed. This system consists of three-dimensional microchannel and microchamber network, in which nanoliter sized multiple droplets can be accurately metered and mixed simultaneously. Liquid operation was realized using pneumatic pressure due to the hydrophobic surface nature of PDMS microdevice. With this device, single injection of liquid is enough to prepare various sized aliquots, and by mixing two different kinds of liquids, concentration gradient can easily be generated. This system can further be applied to chemical or biochemical analysis, such as, high-throughput screening or blood analysis for point-of-care diagnosis.

Keywords

biochemistry; chemical analysis; drops; microfluidics; PDMS microdevice; accurately metered; aliquots; biochemical analysis; blood analysis; chemical analysis; generating concentration gradients; high-throughput screening; hydrophobic surface nature; liquid operation; microfluidic chamber array; mixed; nanoliter sized multiple droplets; pneumatic pressure; point-of-care diagnosis; Biochemical analysis; Chemicals; Chemistry; Fabrication; Liquids; Microchannel; Microfluidics; Surface treatment; Valves; Vents;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE The Sixteenth Annual International Conference on

ISSN

1084-6999

Print_ISBN

0-7803-7744-3

Type

conf

DOI

10.1109/MEMSYS.2003.1189757

Filename

1189757