Knowledge based system for supporting genomic based personalized medicine

Single Nucleotide Polymorphisms (SNP) is one of some types of genetic variations in human´s DNA. SNP can be related to risk of disease´s emergence and/or specific body´s response to certain medicine. SNP has been used to analyse disease´s emergence and body´s response to medicine in some commercial direct-to-consumer (DTC) DNA test. But, based on research conducted by United States Government Accountability Office (GAO), the result of DTC DNA tests was questionable. Therefore, we offer to develop a knowledge based system for analyzing human´s SNP. The knowledge based will use validated SNP public database as the knowledge base. The knowledge based was implemented using MySQL database and the knowledge based system application was built using PHP language. Inference method used in the application was implemented using hypothesize and test method.