Title :
Parallel Microfluidic Synthesis of Conductive Biopolymers
Author :
Xiang, Yu ; LaVan, David
Author_Institution :
Dept. of Mech. Eng., Yale Univ., New Haven, CT
Abstract :
Microfluidic devices with increasing complexity have been demonstrated for a broad range of applications from biological studies, combinatorial synthesis, to fully programmable DNA synthesis. We are using microfluidic devices to synthesize arrays of conductive polymers to select those materials with optimal neural cell attachment and growth support. We have developed a microfluidic based parallel synthesis reactor to automate the creation and evaluation of poly(Pyrrole) based biopolymers. A prototype that is capable of synthesizing and screening over 100 compositions on a chip has been tested. The system currently produces features of ~50 micrometers. Recent work has started to scale up the number of compositions using devices based on immiscible liquid plugs
Keywords :
bioMEMS; conducting polymers; lab-on-a-chip; microfluidics; microreactors; neurophysiology; bioMEMS; biological study; combinatorial synthesis; conductive polymers; growth support; lab-on-a-chip; liquid plugs; microfluidic devices; neural cell attachment; parallel microfluidic synthesis conductive biopolymers; parallel synthesis reactor; polypyrrole; programmable DNA synthesis; Microfluidics; BioMEMS; Lab-on-a-chip; combinatorial method; conductive polymers; microfluidics; parallel synthesis; pyrrole;
Conference_Titel :
Mechatronic and Embedded Systems and Applications, Proceedings of the 2nd IEEE/ASME International Conference on
Conference_Location :
Beijing
Print_ISBN :
0-7803-9721-5
DOI :
10.1109/MESA.2006.296944
