DocumentCode
3343669
Title
Notice of Retraction
Influence of BBP Exposure on mRNA Transcription of AChE, SOD and CYP4501A in Danio rerio
Author
Zhang Can ; Yang Xue ; He Zhen ; Hu Xiao-jing ; Zhong Qiu ; Guo Jia ; Wang Jinlong ; Xiong Li ; Liu De-li
Author_Institution
Hubei Key Lab. of Genetic Regul. & Integrative Biol., Huazhong Normal Univ., Wuhan, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
In order to observe the toxic effects of butyl benzyl phthalate (BBP) on Danio rerio, the mRNA transcription of AChE, SOD, CYP4501A in Danio rerio brain and muscle were studied in this paper. Zebrafish were exposed to different BBP concentrations (0, 0.332, 0.665, 1.33 mg-L-1). The results of semi-quantitative RT-PCR indicated that, both in brain and muscle, Acetylcholinesterase (AChE) gene expression showed a overall downward trend, and at 0.665 mg-L-1 concentration group was significantly inhibited (p <;0.01); Superoxide dismutase (SOD) gene expression was first decreased and then increased; Cytochrome P450 (CYP450 1A) gene expression in brain was first increased and then decreased, while it was first decreased and then increased in muscle, this difference may be related to the differencial distribution of CYP4501A in vivo.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
In order to observe the toxic effects of butyl benzyl phthalate (BBP) on Danio rerio, the mRNA transcription of AChE, SOD, CYP4501A in Danio rerio brain and muscle were studied in this paper. Zebrafish were exposed to different BBP concentrations (0, 0.332, 0.665, 1.33 mg-L-1). The results of semi-quantitative RT-PCR indicated that, both in brain and muscle, Acetylcholinesterase (AChE) gene expression showed a overall downward trend, and at 0.665 mg-L-1 concentration group was significantly inhibited (p <;0.01); Superoxide dismutase (SOD) gene expression was first decreased and then increased; Cytochrome P450 (CYP450 1A) gene expression in brain was first increased and then decreased, while it was first decreased and then increased in muscle, this difference may be related to the differencial distribution of CYP4501A in vivo.
Keywords
biochemistry; biological techniques; brain; cellular biophysics; enzymes; genetics; molecular biophysics; molecular configurations; muscle; organic compounds; plasticisers; AChE; CYP4501A; acetylcholinesterase gene expression; brain; butyl benzyl phthalate effects; cytochrome P450; danio rerio; mRNA transcription; muscle; plasticizer; semiquantitative RT-PCR analysis; superoxide dismutase; toxic BBP exposure; zebrafish; Biochemistry; Chemicals; Gene expression; In vivo; Marine animals; Muscles; RNA;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5781417
Filename
5781417
Link To Document