DocumentCode
3343850
Title
Notice of Retraction
Effects of Lead in Drinking Water on Biochemical Alterations in Multi-Organs of Mice
Author
Daozong Xia ; Jiaqi Guan ; Yeping Ruan ; Xinfen Yu
Author_Institution
Coll. of Pharm. Sci., Zhejiang Chinese Med. Univ., Hangzhou, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The present study was conducted to investigate the effects of lead in drinking water on biochemical alterations in brain, liver and kidney of mice. The biochemical alterations and antioxidant enzymes in different treated mice were determined by commercial kits. The metal concentrations were measured using atomic absorption spectrophotometer (AAS). The results showed that lead acetate with different concentrations of 100, 200 and 300 mg/L, which could significantly increase GSH level and CAT activities, and lower the GSSG and TBARS level in brain, liver and kidney of mice. Furthermore, the changes of biochemical alterations and antioxidant enzymes had concentration-dependent relations. Brain SOD activity in different treated mice had obviously increase, which with the concentration-dependent manner. This study also suggested that lead concentration in blood, brain, liver and kidney of mice significantly increased after lead exposed in drinking water with different concentrations. Like the biochemical parameters, lead concentration in blood, brain, liver and kidney of different mice has obvious concentration-dependent relations. Compared with normal group, the percentage of increased blood lead level was 210-285%, brain lead level was 164-318%, liver lead level was 205-628% and kidney level was 424-816% in lead exposed mice, respectively. In conclusion, this study reported that lead acetate capable of causing marked oxidative damage in addition to inhibiting the activities of antioxidant enzymes with low level in d- veloping mice. Furthermore, the changes of biochemical alterations had significant concentration-dependent manner.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The present study was conducted to investigate the effects of lead in drinking water on biochemical alterations in brain, liver and kidney of mice. The biochemical alterations and antioxidant enzymes in different treated mice were determined by commercial kits. The metal concentrations were measured using atomic absorption spectrophotometer (AAS). The results showed that lead acetate with different concentrations of 100, 200 and 300 mg/L, which could significantly increase GSH level and CAT activities, and lower the GSSG and TBARS level in brain, liver and kidney of mice. Furthermore, the changes of biochemical alterations and antioxidant enzymes had concentration-dependent relations. Brain SOD activity in different treated mice had obviously increase, which with the concentration-dependent manner. This study also suggested that lead concentration in blood, brain, liver and kidney of mice significantly increased after lead exposed in drinking water with different concentrations. Like the biochemical parameters, lead concentration in blood, brain, liver and kidney of different mice has obvious concentration-dependent relations. Compared with normal group, the percentage of increased blood lead level was 210-285%, brain lead level was 164-318%, liver lead level was 205-628% and kidney level was 424-816% in lead exposed mice, respectively. In conclusion, this study reported that lead acetate capable of causing marked oxidative damage in addition to inhibiting the activities of antioxidant enzymes with low level in d- veloping mice. Furthermore, the changes of biochemical alterations had significant concentration-dependent manner.
Keywords
biochemistry; blood; brain; enzymes; kidney; lead; liver; spectrochemical analysis; toxicology; water; water pollution; H2O; Pb; SOD activity; antioxidant enzymes; atomic absorption spectrophotometer; biochemical alterations; blood; brain; drinking water; kidney; lead; liver; mice; multiorgans; Blood; Kidney; Lead; Liver; Mice; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5781427
Filename
5781427
Link To Document