Cytotoxicity of COB materials

Author

Uhlemann, Jürgen ; Schindler, Sebastian ; Schlottig, Gerd ; Drechsler, Maik ; Starcke, Susanne ; Vollmer, Günter ; Wolter, Klaus-Jürgen

Author_Institution

Electron. Packaging Lab., Technische Univ. Dresden, Germany

fYear

2005

fDate

31 May-3 June 2005

Firstpage

593

Abstract

The standards DIN EN ISO 10992 Part 1: 12-2003 and Part 5:11-1999 demand different tests for cytotoxicity including in vitro methods for evaluation materials in application of medical devices. Special features are materials for packaging processes in the field of medical micro devices. In this context the working group selected fundamental systems of materials and contact layers for testing in contact with the standard cell 3T3 clone A 31 and NCTC clone L929. One of the advanced methods includes a spectroscopic measurement of the metabolism. The results permit a gentle differentiation of materials cytotoxicity. Examples are shown in this paper.

Keywords

biomedical electronics; biomedical equipment; chip-on-board packaging; health hazards; materials testing; COB materials; biomedical electronics; biomedical equipment; chip-on-board packaging; evaluation materials; health hazards; material cytotoxicity; medical devices; medical micro devices; packaging materials; Biological materials; Ceramics; Cloning; Dielectric materials; Dielectric substrates; Gold; ISO standards; Lamination; Materials testing; Packaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronic Components and Technology Conference, 2005. Proceedings. 55th

ISSN

0569-5503

Print_ISBN

0-7803-8907-7

Type

conf

DOI

10.1109/ECTC.2005.1441329

Filename

1441329