Notice of RetractionISL-Induced Differentiation Is Associated with NADPH Oxidase in HL-60 Cells

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

In our previous study, we have found that the intracellular reactive oxygen species (iROS) to mediate the monocytic differentiation in leukemia cells (HL-60) induced by isoliquiritigennin(ISL), NADPH oxidase is the main source of reactive oxygen species in the cell. In order to find out the relationship between ISL-induced differentiation and NADPH oxidases, the content of Superoxide anions (O₂^-) was detected. ISL increased intracellular Superoxide anions (O₂^-) that was completely inhibited by the NADPH oxidase inhibitor DPI and APO. ISL increased NBT reduction ability and the expressions of surface antigens CDllb were completely inhibited by DPI and APO. Our data suggest that NADPH oxidase-mediated generation of ROS is an important contributor to ISL-induced HL-60 cell differentiation.